4000-520-616
欢迎来到免疫在线!(蚂蚁淘生物旗下平台)  请登录 |  免费注册 |  询价篮
主营:原厂直采,平行进口,授权代理(蚂蚁淘为您服务)
咨询热线电话
4000-520-616
当前位置: 首页 > 产品中心 > > goprolytix/Domain Structure of Fibronectin/2 mg/HCFN-0170
商品详细goprolytix/Domain Structure of Fibronectin/2 mg/HCFN-0170
goprolytix/Domain Structure of Fibronectin/2 mg/HCFN-0170
goprolytix/Domain Structure of Fibronectin/2 mg/HCFN-0170
商品编号: HCFN-0170
市场价: ¥0.00
美元价: 0.00
产地: 美国(厂家直采)
公司:
产品分类: 其他
公司分类:
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Fibronectin (cold-insoluble globulin) is a high molecular weight, adhesive, glycoprotein found in both plasma (1) and the extracellular matrix (2). Fibronectin is composed of two peptide chains of approximately 275,000 molecular weight which are linked through two interchain disulfide bonds at the COOH-terminal end of the molecule (3). The structure of fibronectin is characterized by three different types of repeating homologous sequence units (4,5). The 45 amino acid type-I repeat constitutes the NH2- and COOH-terminal ends of the protein. The two 60 amino acid type-II segments follow the first nine type-I repeats at the NH2-terminus. The 90 amino acid type-III segments occupy the central region of the fibronectin molecule. Structural differences between plasma and cellular fibronectin (6,7) as well as between the two subunits of plasma fibronectin (8,9) have been identified. These differences likely originate due to transcriptional and posttranscriptional events involving mRNA splicing (10).

The apparent function of fibronectin is to mediate cell attachment by interacting with cell surface receptors and extracellular matrix components (10-12). Fibronectin contains an Arg-Gly-Asp-Ser (RGDS) cell attachment-promoting sequence within one of the type-III homology segments in the middle of the molecule (13). This RGDS site is recognized by specific RGDS-dependent cell receptors (13) which are members of the integrin family of proteins (14). Fibronectin binding to activated platelets (15) is mediated through the RGDS cell adhesion sequence (16). Other binding domains specific for such extracellular macromolecules as heparin, fibrin(ogen), and collagen (10-12) have been identified and may be important in the fibronectin-mediated adhesion of platelets to the extracellular matrix of endothelial cells (17). Fibrin-fibronectin complexes are stabilized by the factor XIIIa-catalyzed covalent cross-linking of fibronectin to the a chain of fibrin (18).

Fibronectin is isolated from human plasma by thermal precipitation, ion exchange, and gelatin-agarose affinity chromatography. The purified protein is supplied as a lyophilizate. Purity is assessed by SDS-PAGE analysis.

品牌介绍
Prolytix(前身为Haematologic Technologies)于1987年由血栓形成和止血领域的杰出科学家Kenneth Mann博士创立,并迅速成为一家备受推崇的研究试剂公司。凭借在凝血和止血方面的专业知识,我们继续为世界各地的研究实验室提供高纯度的血浆蛋白和抗体。